Sox17 modulates Wnt3A/β-catenin-mediated transcriptional activation of the Lef-1 promoter
نویسندگان
چکیده
منابع مشابه
transcriptional activation of the Lef - 1 promoter - catenin - mediated β Sox 17 modulates Wnt 3 A
integrative aspects of normal and abnormal function of cells and components of the respiratory system. It is published 12 times a publishes original research covering the broad scope of molecular, cellular, and
متن کاملPITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter.
PITX2, beta-catenin and lymphoid enhancer factor (LEF-1) are required for the inductive formation of several epithelial-derived organs, including teeth. Lef-1 is expressed in the dental epithelium after Pitx2, and both factors have overlapping expression patterns in the tooth bud and cap stages. Our analysis of Pitx2-/- mutant mice showed reduced Lef-1 expression in facial tissues by RT-PCR and...
متن کاملWnt-induced transcriptional activation is exclusively mediated by TCF/LEF.
Active canonical Wnt signaling results in recruitment of β-catenin to DNA by TCF/LEF family members, leading to transcriptional activation of TCF target genes. However, additional transcription factors have been suggested to recruit β-catenin and tether it to DNA. Here, we describe the genome-wide pattern of β-catenin DNA binding in murine intestinal epithelium, Wnt-responsive colorectal cancer...
متن کاملDifferential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.
beta-Catenin and plakoglobin are highly homologous components of cell-cell adherens junctions linking cadherin receptors to the actin cytoskeleton. beta-Catenin, in addition, activates transcription by forming a complex with LEF/TCF family transcription factors in the nucleus. Plakoglobin can also bind to LEF-1 and, when overexpressed in mammalian cells, enhances LEF-1-directed transcription. P...
متن کاملWnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter.
Members of the Wnt family of secreted molecules have been established as key factors in determining cell fate and morphogenic signaling. It has long been recognized that Wnt induces morphogenic signaling through the Tcf/LEF-1 cascade by regulating free intracellular levels of beta-catenin, a co-factor for Tcf/LEF-1 transcription factors. In the present study, we have demonstrated that Wnt-3A ca...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2010
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00140.2010